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This Web Site is meant to share information of HIV Gay life in South Florida as we know it. By using this website, you agree that you have read the Website Disclaimer and agree to the exclusions and limitations of liability set out in the Website Disclaimer are reasonable.

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PositiveAttitudes

 

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At the 11-14 meeting we raised $25 bringing our total to:

 

Click here for Advance Tickets

2331A651-89F2-4770-8A0E-6FD4C3D73C3C

B4599861-EE58-4694-A25D-036C977CB487

Friday Movie  Nov 16

BOY ERASED

GATEWAY THEATRE

7 pm

Stars Nicole Kidman

Jared Eamons, the son of a small-town Baptist pastor, must overcome the fallout after being outed as gay to his parents. His father and mother struggle to reconcile their love for their son with their beliefs. Fearing a loss of family, friends and community, Jared is pressured into attending a conversion therapy program. While there, Jared comes into conflict with its leader and begins his journey to finding his own voice and accepting his true self.

 

 

SAVE THE DATE: 12-19-18

POZitive Attitudes

HOLIDAY EVENING POOL PARTY

 Home of

John Ramos & Tim Caldwell

3437 NE 18th Ave, Oakland Park, 33306  

Wednesday, December 19, 2018

7 PM – 9 PM

  • Cocktails & Drinks Provided
  • Bring Pot Luck
  • Annual Gift Exchange ($15 max)
  • Casual Attire (Swim Suits Encouraged)

 

RSVP Required:

 Text 954-579-4158 or Jramos4000@aol.com.

 

 

 

 

 

Related image

 

 

2331A651-89F2-4770-8A0E-6FD4C3D73C3C

B4599861-EE58-4694-A25D-036C977CB487

Friday Movie  Nov 16

BOY ERASED

GATEWAY THEATRE

7 pm

Stars Nicole Kidman

Jared Eamons, the son of a small-town Baptist pastor, must overcome the fallout after being outed as gay to his parents. His father and mother struggle to reconcile their love for their son with their beliefs. Fearing a loss of family, friends and community, Jared is pressured into attending a conversion therapy program. While there, Jared comes into conflict with its leader and begins his journey to finding his own voice and accepting his true self.

 

 

D66AA95A-57A4-46B9-B5B0-2E5E41818554

Potential HIV Cure

A Phase I/IIa trial found that an Israeli biotech’s drug reduces a patient’s HIV levels by up to 99%, and might one day be a cure for the infection.

The trial, run by Zion Medical, found that the synthetic peptide drug reduced the level of viral RNA in patients’ blood by up to 90% after five weeks. In combination with the approved HIV drugs lopinavir and ritonavir, it reduced viral RNA levels by up to 99% after five weeks.

Not only did the drug reportedly lack side-effects, but it also increased the amount of T cells in the patients, a sign of a healthy immune system.

These results on their own are only confirming that Zion’s drug reduces blood viral RNA levels, as approved antiretroviral drugs do. However, the company said that the trial also reaffirmed preclinical trials showing the effectiveness of the drug in killing infected cells.

These first clinical results were beyond our expectations and promise hope in finding a cure for a disease that was discovered over 35 years ago,” stated Esmira Naftali, Chief Operation and Development Officer at Zion.

The drug, licensed from the Hebrew University of Jerusalem, is now continuing into a Phase IIb trial to test its long-term effects in 50 patients.

While approved antiretroviral drugs reduce viral RNA in the blood, they cannot permanently shut down HIV-infected cells, which serve as hidden HIV virus factories.

In contrast, Zion’s drug is designed to eliminate HIV and the infected cells by activating integrase, the enzyme that HIV uses to insert viral DNA into the host cell’s genome. Integrase then inserts too much viral DNA into the cell, blowing the virus’s cover and making the cell commit suicide.

[Our drug’s] treatment mechanism is to reduce viral load through affecting the infected cells, which keep on producing more viruses,” Naftali told me. “With [antiretrovirals], once reaching undetected levels of viral load in the plasma, infected cells are still remaining.

This mechanism of action is particularly interesting due to the way it activates integrase, whereas some antiretrovirals such as raltegravir inhibit the same enzyme to stop the virus inserting its DNA into host cells.

Other companies are racing to develop cures for HIV. Last year, the French company Abivax had a positive Phase IIa trial of its small molecule which attacks the HIV ‘reservoir’ hiding in infected cells. The Spanish company Aelix and Gilead have partnered up to develop a vaccine that reduces the HIV reservoir. Sangamo is also working on a Phase I/II trial of a cell therapy that gives immune cells resistance to HIV infection. 

ARTICLE

The topic this Wednesday November 14, 2018 is Gratitude.    We do this every year in November as part of our Thanksgiving celebration.    Our Thanksgiving pot luck will be the following week, November 21, the Wednesday before Thanksgiving.